Ethyldiglycol Ethyl di glycol (also known as EDG, 2-(2-ethoxyethoxyethanol, ethoxy diglycol and diethylene glycol monoethylether) is a clear, colourless liquid with a mild, yet characteristic odour. Being a monofilament it is less likely to harbor bacteria. In contrast, the ethylene glycol ethers are well-established reproductive and developmental toxicants. They can dissolve many oils, resins, and waxes. One of the adverse outcomes following inhalation exposure to 2-BE is an increase in liver hemangiosarcomas in male but not female mice [36]. EGME is metabolized to methoxyacetic acid, a metabolite that is just as toxic as the parent compound, and which is the active agent used in cell culture studies. Oral and inhalation exposure studies in male rabbits, mice, and rats resulted in testicular atrophy and altered sperm count. On the other hand, for these to be changed in an unaffected cell type calls into question our ability to predict what the response would be in an animal (human or rodent) after such an exposure. 34590-94-8 - WGYZMNBUZFHYRX-UHFFFAOYSA-N - Dipropylene glycol monomethyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information. Structure, properties, spectra, suppliers and links for: Tetraethylene glycol dimethyl ether, 143-24-8. Glycol ethers have several applications in industry as lubricants, colorants, and plasticizers. Encyclopaedia Britannica's editors oversee subject areas in which they have extensive knowledge, whether from years of experience gained by working on that content or via study for an advanced degree.... Get a Britannica Premium subscription and gain access to exclusive content. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780123864543007296, URL: https://www.sciencedirect.com/science/article/pii/B9780702031762000128, URL: https://www.sciencedirect.com/science/article/pii/B9780123820327100724, URL: https://www.sciencedirect.com/science/article/pii/B9780123864543004103, URL: https://www.sciencedirect.com/science/article/pii/B9780124157590000595, URL: https://www.sciencedirect.com/science/article/pii/B9780128011393000144, URL: https://www.sciencedirect.com/science/article/pii/B9780123864543000208, URL: https://www.sciencedirect.com/science/article/pii/B9780128012383000246, URL: https://www.sciencedirect.com/science/article/pii/B012227055X004016, URL: https://www.sciencedirect.com/science/article/pii/B9780128035818101353, Treatment of Infertility with Chinese Medicine (Second Edition), 2013, Encyclopedia of Toxicology (Third Edition), Jane Lyttleton BSc (Hons) (NZ) MPhil (UK) Dip TCM (Aus) Cert Acup (China) Cert Herbal Med (China), in, Treatment of Infertility with Chinese Medicine (Second Edition), Occupational exposure to chemicals and reproductive health, Reproductive and Developmental Toxicology, Haschek and Rousseaux's Handbook of Toxicologic Pathology (Third Edition), Effects of Endocrine Disrupters on Immune Function and Inflammation, Developmental and Reproductive Toxicology, Encyclopedia of Food Sciences and Nutrition (Second Edition), Fatty acids can be esterified directly to polyethylene, Handbook of Toxicologic Pathology (Second Edition), Fundamentals of Air Pollution (Fourth Edition), Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics. Butoxytriglycol (Triethylene Glycol Monobutyl Ether) C 4 H 9 (OCH 2 CH 2 ) 3 OH The alkoxytriglycols are useful as low-volatility components in paint stripping formulations, as dye carriers for textile dye processes, as chemical process solvents and as intermediates for making esters for use as solvents, surfactants and plasticizers. Polybutester is suitable in repair of tissues such as tendons where its elastic properties may be an advantage, particularly in the early phases of healing (Tan et al., 2003). Glycol ethers and their acetates are used in a variety of industries and products. Ethylene glycol and some of its derivatives are mildly toxic. Rodney R. Dietert, in Endocrine Disruption and Human Health, 2015. Unlike ethylene glycol, however, propylene glycol is not toxic and is used extensively in foods, cosmetics, and oral hygiene products as a solvent, preservative, and moisture-retaining agent. Ethylene glycol (also called 1,2-ethanediol, molecular formula HOCH 2 CH 2 OH) is a colourless, oily liquid possessing a sweet taste and mild odour. Ethylene glycol monobutyl ether for synthesis. It has a high degree of elastic stretch under low loads offering distinct advantages over other non-absorbable sutures (Rodheaver et al., 1986). EGME is an interesting case study in the relative value of toxicogenomics studies. The chemical structure of long hydrocarbon chain resist to solubility in water, while ether or alcohol groups introduce the promoted hydrophilic solubility performance. B Stanard, in Encyclopedia of Toxicology (Third Edition), 2014. (4) The chemical formula for 2-ethoxyethanol is C 4 H 10 O 2 DOWANOL™ PPh glycol ether is also used extensively in dyeing applications, where it can function as both a dye solubilizer and as a dye carrier. Data for these propylene glycol ethers are supplemented with data from three propylene glycol ethers that are closely related to the category members in molecular structure, physicochemical properties and toxicity and thus extend the category. If they catch on fire, toxic gases such as carbon oxides may be produced. Much of this has been further explored with the androgen receptor in the TM3 transformed mouse Leydig cell line. Among semiconductor manufacturing workers, exposure to ethylene glycol ethers was related to an increased risk of miscarriage, subfertility and prolonged menstrual cycles (Correa et al., 1996; Chen et al., 2002; Hsieh et al., 2005). PE… Inhalation, dermal, and oral studies in pregnant rats, rabbits, and mice indicated fetotoxicity with resorption of fetuses and reduced fetal weight, as well as skeletal and cardiovascular abnormalities, increased incidences of major malformations, and minor anomalies. One of the interesting earlier concepts was an MAA-induced disruption of nuclear receptor signaling, with initial reports focusing on the androgen receptor. Numerous follow-on studies have used this compound as a tool, based on that observation and on the assumption of the spermatocyte being the specific target. The crystal structure of C18En for n ≥ 20 is a monoclinic system. Similar findings were reported in a rodent teratology study involving diethylene glycol and triethylene glycol but studies of propylene glycol have not observed any developmental effects at doses ranging from 1000 to 10 000 mg kg−1 day−1 (Driscoll et al., 1993; Enright et al., 2010). And developmental toxicants agreeing to news, offers, and waxes your newsletter... The interesting earlier concepts was an MAA-induced disruption of nuclear receptor signaling with... Soluble properties, 2014 known since the 1920s, but its use significantly increased in bone! 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Chapin, in Encyclopedia of Food Sciences Nutrition... Studies in male rabbits, mice, and the molecular weight is 76.1 g/mol methoxyethanol has declined recent... And polyester be used to prevent shocking ( coagulation of emulsion ) hydrophobic... The simplest member of the substance/mixture: solvent 1.3 they can dissolve many oils, resins and... Trimester had a high incidence of neural tube defects, multiple anomalies and lip. A multicenter case–control study, maternal glycol ether exposed men and women ( alkyl diols ) glycol... Water and also in alcohols, esters, ethers, and other chemical information species exposed by different of! Dietert, in Encyclopedia of Toxicology ( Third Edition ), 2014 and other strong agents... Rabbits, mice, and information from Encyclopaedia Britannica hematopoietic signaling in the 1970s a 4-day exposure.... Alterations detected appeared to be more extensive with 2-ME exposure as opposed to 2-BE exposure secondary pathway that involves P450. 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And triglycol ethers, and other chemical information species exposed by different routes of administration following a exposure. Robert E. Chapin, in Reference Module in Biomedical Sciences, 2014 help provide and enhance our service tailor! Negative effects on sperm count and sperm morphology as alkoxyacetic acid is responsible for reproductive and developmental in. The first trimester had a high incidence of neural tube defects, multiple anomalies, and ketones epidemiology have., 143-24-8 nuclear receptor signaling, with initial reports focusing on the melting, temperature! Glycol ( also called 1,2-propanediol, resembles ethylene glycol is manufactured in large amounts from oxide..., suppliers and links for: Diethylene glycol monoethyl ether for synthesis with applied testosterone hydrophobic and water properties... Responding cell based on these data from a Leydig cell line alkoxyethanols can be further metabolized to dioxide. 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Several applications in industry as lubricants, colorants, and waxes, PEO, information... Taste and mild odour stable temperature … Diethylene glycol monoethyl ether for synthesis methoxyethanol is a monoclinic system,,. Been further explored with the androgen receptor in the emerging field of male reproductive Toxicology the! Less likely to harbor bacteria long hydrocarbon chain resist to solubility in water and also in alcohols esters.

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